摘要
轻度认知功能障碍(MCI)是介于正常认知功能和痴呆之间的过渡阶段,常好发于老年人,其主要临床表现为注意力、记忆力、定向力和执行能力等方面的衰退,严重影响患者的生活质量,且MCI向阿尔茨海默病(AD)的转化率高于普通人群.笔者通过查阅国内外相关文献,发现中医外治法治疗MCI具有疗效确切、操作简便、不良反应少等优势,主要包括灸法、针刺疗法、传统养生功法以及耳穴疗法等.中医外治法可通过诱导神经突触可塑性、增加脑血流量及保护脑组织细胞、促进炎症因子及氧化应激反应平衡、调节脑源性神经营养因子的表达、调节神经递质释放等机制促进MCI患者中枢神经系统功能修复.
Abstract
Mild cognitive impairment(MCI)is a transitional stage between normal cognitive function and dementia.It usually occurs in the elderly and its main clinical manifestations are decline in attention,memory,orientation and executive ability.The disease seriously affects the quality of life of patients,and the conversion rate of MCI to Alzheimer's disease(AD)is higher than that of the general population.By referring to relevant literature at home and abroad,the authors found that the external treatment of MCI has the advantages of precise efficacy,simple operation,less adverse reactions,including moxibustion,acupuncture,traditional health exercise and auricular point therapy.External treatment of Chinese medicine can promote the functional repair of central nervous system in MCI patients by inducing synaptic plasticity,increasing cerebral blood flow,protecting brain tissue cells,promoting the balance of inflammatory factors and oxidative stress response,regulating the expression of brain-derived neurotrophic factor,and regulating the release of neurotransmitters.
基金项目
福建省自然科学基金资助项目(2021J01902)
维普
万方数据