Diabetic kidney disease(DKD)is one of the most common complications of diabetes mellitus(DM)and can progress to end-stage renal disease,significantly reducing patients' quality of life.Mitochondrial autophagy selectively clears damaged or dysfunctional mitochondria through autophagy mechanisms to maintain mitochondrial quality control and homeostasis,representing a form of autophagy.Studies have shown that mitochondrial autophagy plays a crucial role in the occurrence and development of DKD.Therefore,preventing and treating DKD from the perspective of mitochondrial autophagy has become a research hotspot.Traditional Chinese Medicine(TCM)has comprehensive,multi-targeted therapeutic advantages.This paper reviews the research progress on TCM treatment of DKD through the regulation of mitochondrial autophagy pathways and related signaling pathways.It is found that some tonifying medicines,blood-activating medicines,diuretic dampness-percolating medicines,and heat-clearing detoxifying medicines,either as monomers or compounds,can regulate mitochondrial autophagy through PINK1/Parkin,FUNDC1,AMPK/SIRT1,and other signaling pathways,thereby effectively delaying the progression of DKD.
关键词
线粒体自噬/信号通路/糖尿病肾脏病/中药
Key words
Mitochondrial autophagy/Signaling pathways/Diabetic kidney disease/Chinese herbal medicine
维普
万方数据