Effects of Danggui Shaoyao Powder Combined with Enoxaparin on Sex Hormone Levels,Coagulation Function,and Pregnancy Outcomes in Patients with Recurrent Miscarriage
Objective:To investigate the clinical efficacy of Danggui Shaoyao Powder combined with enoxaparin on recurrent miscarriage patients,and its effects on sex hormones,coagulation parameters,and pregnancy outcomes.Methods:A total of 102 patients with recurrent miscarriage meeting the inclusion criteria were randomly divided into a control group and an observation group,with 51 cases in each group.The control group received enoxaparin treatment,while the observation group received the same plus Danggui Shaoyao Powder,continuing until the 12th week of pregnancy.Traditional Chinese medicine(TCM)syndrome scores,endometrial receptivity indicators[spiral artery resistance index(RI),blood flow pulsatility index(PI),endometrial thickness,uterine volume],estrogen and progesterone levels[estradiol(E2),progesterone(P),β-human chorionic gonadotropin(β-HCG)],coagulation parameters[thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D)],and hemorheological parameters[erythrocyte sedimentation rate(ESR),plasma viscosity(PV),high shear whole blood viscosity(BVH),low shear whole blood viscosity(BVL)]were compared between the two groups,along with pregnancy preservation outcomes(preterm birth rate,full-term delivery rate,and pregnancy preservation success rate).Results:After treatment,the main and secondary symptoms and total scores of TCM syndrome in both groups decreased(P<0.05);RI and uterine volume decreased(P<0.05),endometrial thickness increased(P<0.05),and β-HCG,P,E2,TT,APTT,and PT levels significantly increased(P<0.05),while D-D,PV,BVH,and ESR levels decreased(P<0.05).PI and BVL decreased significantly in the observation group(P<0.05).Post-treatment improvements in TCM syndrome scores,estrogen and progesterone levels,coagulation parameters,hemorheological indicators,RI,uterine volume,and endometrial thickness were all significantly better in the observation group compared to the control group(P<0.01).The preterm birth rate in the observation group(3.92%,2/51)was significantly lower than that in the control group(13.73%,7/51)(P<0.05),while the full-term delivery rate(86.27%,44/51)and pregnancy preservation success rate(90.20%,46/51)were significantly higher than those in the control group(62.75%,32/51)and(76.47%,39/51)(P<0.05).Conclusion:Danggui Shaoyao Powder combined with enoxaparin is more effective than enoxaparin alone for treating recurrent miscarriage.It can effectively improve TCM syndrome,endometrial receptivity,coagulation function,and hemorheological indicators,thereby enhancing pregnancy preservation success rates.
万方数据
维普
