Clinical outcomes of promoting blood circulation and removing blood stasis Chinese patent drugs for adjuvant treatment of cervical spondylotic radiculopathy:a network meta-analysis
Objective:To systematically review the clinical outcomes of different Chinese patent drugs for promoting blood circulation and removing blood stasis in adjuvant treatment of cervical spondylotic radiculopathy(CSR).Methods:All the randomized controlled trial(RCT)articles about promoting blood circulation and removing blood stasis Chinese patent drugs for adjuvant treatment of CSR included from database establishing to September 20,2023 were retrieved from the China National Knowledge Internet,Vip Database,Wanfang Data-base,PubMed,Web of Science and Cochrane Library through computer.The patients in experiment group were treated with conventional non-surgical therapies and oral application of Chinese patent drugs for promoting blood circulation and removing blood stasis,while the ones in control group with conventional non-surgical therapies alone.The articles were screened according to the retrieval and screening scheme.The information was extracted and the methodological quality of included researches in the articles was evaluated independently by two re-searchers.The reticulation plots were drawn by using Stata18.0 software,and then a reticulated Meta-analysis on clinical effective rate,neck pain visual analogue scale(VAS)score,and neck disability index(NDI)was conducted;Furthermore,the outcomes of the therapies were ranked according to the surface under the cumulative ranking curve(SUCRA),and the publication bias was tested by using comparison-cor-rection funnel plots.Results:Six thousand seven hundred and sixty-eight articles were searched out.After screening,28 articles were include-ed in the final analysis,involving six kinds of Chinese patent drugs for promoting blood circulation and removing blood stasis,i.e.,Jingtong(颈痛,JT)granule,Jingshu(颈舒,JS)granule,Jitongxiao(脊痛消,JTX)capsule,Biqi(痹祺,BQ)capsule,Shujin Tongluo(舒筋通络,SJTL)granule and Jingfukan(颈复康,JFK)granule.The results of reticulated Meta-analysis showed that,in adjuvant treatment of CSR,JT granule combined with conventional therapy(CT)(SUCRA =78.4%)behaved best in clinical effective rate,followed by BQ capsule com-bined with CT(SUCRA = 71.6%),JS granule combined with CT(SUCRA = 62.1%),SJTL granule combined with CT(SUCRA = 53.7%),JTX capsule combined with CT(SUCRA =43.3%),JFK granule combined with CT(SUCRA =40.5%)and CT(SUCRA = 0.4%);and SJTL granule combined with CT(SUCRA =96.3%)behaved best in neck pain VAS score,followed by BQ capsule combined with CT(SUCRA=86.2%),JFK granule combined with CT(SUCRA =51.6%),JT granule combined with CT(SUCRA =50.8%),JS granule combined with CT(SUCRA =37.4%),JTX capsule combined with CT(SUCRA =27.4%)and CT(SUCRA =0.4%);and BQ capsule combined with CT(SUCRA =95%)behaved best in NDI,followed by JFK granule combined with CT(SUCRA =71.3%),JT gran-ule combined with CT(SUCRA=69.2%),JTX capsule combined with CT(SUCRA =38.7%),JS granule combined with CT(SUCRA = 20.8%)and CT(SUCRA =5.0%).Conclusion:Available evidences suggest that,in adjuvant treatment of CSR,the JT granule behaves best in the total outcomes,the SJTL granule performs best in alleviating neck pain,and the BQ capsule acts best in improving neck vertebra function.However,due to the difference in non-surgical therapies used in the control group,as well as the limitations in the quantity and quality of the articles,the conclusion here need to be further verified.
NETL
NSTL
万方数据
维普
