Clinical outcome and safety of manipulative reduction combined with percutaneous kyphoplasty for treatment of osteoporotic vertebral compression fracture:a meta-analysis
Objective:To systematically review the clinical outcome and safety of manipulative reduction combined with percutaneous kyphoplasty(PKP)for treatment of osteoporotic vertebral compression fracture(OVCF).Methods:All the clinical controlled trial articles about manipulative reduction combined with PKP for treatment of OVCF included from database's inception to October 1,2023 were re-trieved from the China National Knowledge Infrastructure,Vip Database,Wanfang Database,PubMed and Cochrane Library through comput-er.The patients in observation group were treated with manipulative reduction and PKP,while the ones in control group with PKP alone.The articles were screened according to the inclusion and exclusion criteria.The methodological quality of researches in the included articles was evaluated,and then a Meta-analysis was conducted.Results:Two hundred and thirty-three articles were searched out.After screening,9 Chinese articles were included in the final analysis.The results of Meta-analysis revealed that the pain visual analogue scale(VAS)score was lower,the improvement of kyphotic Cobb angle of injured vertebrae and restoration of anterior border height of vertebral body were better in observation group compared to control group(MD=-0.67,95％CI(-1.15,-0.20),P=0.006;MD=-1.54,95％CI(-2.67,-0.41),P=0.007;MD=2.81,95％CI(2.02,3.59),P=0.000);while,the comparison of Oswestry disability index(ODI)and bone ce-ment leakage incidence rate between the 2 groups revealed no significant differences(MD=-3.99,95％CI(-11.24,3.26),P=0.280;OR=0.48,95％CI(0.21,1.11),P=0.080).Conclusion:Manipulative reduction combined with PKP can effectively relieve pain,im-prove the kyphosis of injured vertebrae,and restore the anterior border height of injured vertebrae in treatment of OVCF,and its curative outcome is better than that of PKP alone;while,both are similar to each other in the improvement of activities of daily living and safety.
spinal fracturesosteoporotic fracturesfractures,compressionkyphoplastybone setting manipulationMeta-analysis as topic
万方数据
维普
