Clinical medication rules of the oral prescriptions for treatment of orthopedic traumatologic diseases(TCM)in Yonglei Qianfang
Objective:To analyze the clinical medication rules of the oral prescriptions for treatment of orthopedic traumatologic disea-ses(TCM)in Yonglei Qianfang.Methods:The oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)were extracted from Yonglei Qianfang and a standard database for the prescriptions was established.The occurrence frequency,medicinal property,medici-nal flavor,meridian tropism and efficacy of the normalized Chinese herbs(CHs)in the included prescriptions were statistically analyzed by using the Microsoft Office Excel 2019 software;the association rules of the CHs involved in the included prescriptions were analyzed by em-ploying SPSS Modeler 18.0 software;and the high-frequency CHs were then subjected to systematic cluster analysis by using SPSS Statistics 26 software.Results:Forty-seven oral prescriptions were included in the final analysis,involving 162 CHs,among which 34 ones displayed a occurrence frequency of ≥5,and the top 6 ones with a high occurrence frequency included Angelicae Sinensis Radix(TCD),Chuanxiong Rhizoma,Angelicae Dahuricae Radix,Radix Aconiti Kusenzoffii,Olibanum(TCD)and Cinnamomi Cortex.The CHs in the 47 oral prescrip-tions are often the ones presented with warm property,pungent,bitter and sweet flavors,and mainly act on liver meridians,spleen meridians and heart meridians with the efficacies mainly as promoting blood circulation to remove blood stasis,tonifying deficiency as well as releasing exterior.The association rule analysis on the 47 oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)yielded 17 as-sociation rules,with the gains of＞1.The association rule with the highest support was Angelicae Sinensis Radix(TCD)→Chuanxiong Rhi-zoma,the ones with a confidence of 100％included Angelicae Sinensis Radix(TCD)→Cinnamomi Cortex+Chuanxiong Rhizoma,Angelicae Sinensis Radix(TCD)→Cinnamomi Cortex+Angelicae Dahuricae Radix and Angelicae Sinensis Radix(TCD)→Myrrha+Chuanxiong Rhi-zoma.The paired-herbs with strong correlation were Chuanxiong Rhizoma-Angelicae Sinensis Radix(TCD),Angelicae Sinensis Radix(TCD)-Cinnamomi Cortex,Angelicae Sinensis Radix(TCD)-Olibanum(TCD),Angelicae Dahuricae Radix-Angelicae Sinensis Radix(TCD)and Myrrha-Olibanum(TCD).The cluster analysis generated 3 new prescriptions,namely pericarpium zanthoxyli-Lycopi Herba-Glycyrrhizae Radix et Rhizoma(TCD)-Angelicae Sinensis Radix(TCD)-Chuanxiong Rhizoma-Cinnamomi Cortex,Angelicae Dahuricae Ra-dix-Platycodonis Radix-Citri Reticulatae Pericarpium-Paeoniae Radix Rubra-Foeniculum Vulgare-Zingiberis Rhizoma Recens-Rehmanniae Radix,and Angelicae Pubescentis Radix(TCD)-Aconiti Kusnezoffii Radix-Zingiberis Rhizoma-Notopterygii Rhizoma et Radix-Atractlodis Rhizoma-Achyranthes Bidentatae Radix(TCD)-Asari Radix et Rhizoma(TCD)-Dipsaci Radix-Polygoni Multiflori Radix(TCD)-Radix Ac-oniti Kusenzoffii-Paeoniae Radix Alba-Drynariae Rhizoma-Momordica cochinchinensis seed-Olibanum(TCD)-Myrrha-Pyritum.Conclusion:The CHs with pungent,bitter and sweet flavors and warm property mainly act on liver meridians,spleen meridians and heart meridians are more preferred in the oral prescriptions aimed at treating orthopedic traumatologic diseases(TCM)in Yonglei Qianfang,which mainly follow the principle of promoting blood circulation to remove blood stasis,tonifying deficiency as well as releasing exterior.The medication rules conform to the thoughts of dispersing cold-pathogen and promoting the flow of Qi and blood.
medicine pharmacologic literature(TCM)Yonglei Qianfangorthopedic traumatologic diseases(TCM)constitution of formu-laformula analysis,computer assisteddata miningcluster analysis
万方数据
维普
