The distribution and change rule of blood stasis syndrome in chronic osteopathy:a modern articles-based study
Objective:To analyze the distribution and change rule of blood stasis syndrome in chronic osteopathy.Methods:All articles about cervical spondylosis(CS),lumbar disc herniation(LDH),femoral head necrosis(FHN),knee osteoarthritis(KOA),and osteoporosis(OP)included from database's inception to December 31,2023 were retrieved from Wanfang Database,China National Knowledge Infra-structure,and Vip Database.The eligible articles were screened according to the inclusion and exclusion criteria,and the traditional Chinese medicine(TCM)syndrome types and syndrome manifestations were extracted from the included articles and were normalized,based on which the distribution and change rule of blood stasis syndrome in chronic osteopathy were analyzed.Results:①Eighteen thousand two hundred and fifty-five articles were searched out.After screening,2929 articles were included in the final analysis,including 731 CS articles,935 LDH articles,301 FHN articles,658 KOA articles,and 304 OP articles.②Twenty blood stasis syndrome-related TCM syndrome types were sorted out,among which the top 5 ones with a high occurrence frequency were qi-stagnation and blood-stasis syndrome,static blood blocking collaterals syndrome,kidney-deficiency and blood-stasis syndrome,qi-deficiency and blood-stasis syndrome as well as phlegm-blood stasis blocking collaterals syndrome.Thebloodstasissyndrome-related TCM syndrometypesaccountedfor88.10%,59.56%and50.57%inthe early,middle and late stage of CS,respectively;95.90%,83.67%and 51.39%in the early,middle and late stage of LDH,respectively;69.44%,58.33%and 50.67%in the early,middle and late stage of FHN,respectively;56.81%,98.35%and 54.61%in the early,mid-dle and late stage of KOA,respectively;and97.62%,51.39%and83.97%in the early,middle and late stage of OP,respectively.After merging the TCM syndrome types of the 5 chronic osteopathies,the proportions of the blood stasis syndrome-related TCM syndrome types were85.8%,74.21%,and50.18%in early,middle and late stages of chronic osteopathy,respectively.③Twenty-nine blood stasis syn-drome-related syndrome manifestations were sorted out,among which the fixed pain-site,refusing press at pain-site,joint stabbing pain,ec-chymosis or petechiae and a dark purple presented in tongue appeared more frequently.The blood stasis syndrome-related syndrome mani-festations accounted for 62.20%,40.55%and 21.13%in the early,middle and late stage of CS,respectively;62.32%,59.25%and 58.25%in the early,middle and late stage of LDH,respectively;50.90%,79.81%and 50.63%in the early,middle and late stage of FHN,respectively;51.02%,65.02%and 46.54%in the early,middle and late stage of KOA,respectively;and 54.40%,44.36%and 66.74%in the early,middle and late stage of OP,respectively.After merging the syndrome manifestations of the 5 chronic osteopathies,the proportions of the blood stasis syndrome-related syndrome manifestations were 57.83%,62.46%,and 52.58%in early,middle and late stages of chronic osteopathy,respectively.④The results of cluster analysis showed that the blood stasis syndrome-related syndrome manifes-tations of CS,LDH,FHN and OP were clustered into three sub-categories,that was early stage,middle stage,and late stage;and the blood stasis syndrome-related syndrome manifestations of KOA were clustered into onset stage,remission stage,and rehabilitation stage,with CS dominated by fixed pain-site,neck stabbing pain,and limb numbness in the early,middle,and late stage,respectively;LDH by refusing press at pain-site,fixed pain-site,and subcutaneous ecchymosis in the early,middle,and late stage,respectively;FHN by hip stabbing pain,rest pain,and muscular atrophy in the early,middle,and late stage,respectively;KOA by fixed pain-site,joint stabbing pain,and skin numb-ness in the onset,remission,and rehabilitation stage,respectively;and OP by dark complexion,low back stabbing pain,and fixed pain-site in the early,middle,and late stage,respectively.The blood stasis syndrome-related syndrome manifestations of the 5 chronic osteopathies were dominated by fixed pain-site,refusing press at pain-site,and muscular atrophy in the early,middle,and late stage,respectively.Conclusion:Blood stasis syndrome exists throughout the entire course of onset and development of chronic osteopathy,and it mainly includes qi-stagna-tion and blood-stasis syndrome,static blood blocking collaterals syndrome,kidney-deficiency and blood-stasis syndrome,qi-deficiency and blood-stasis syndrome as well as phlegm-blood stasis blocking collaterals syndrome.In the early,middle and late stage of chronic osteopa-thy,the blood stasis syndrome mainly manifests as fixed pain-site,refusing press at pain-site,and muscular atrophy,respectively.With the development of the disease,the blood stasis syndrome of spine-related chronic osteopathy shows a pattern of gradual decrease,the blood sta-sis syndrome of joint-related chronic osteopathy shows a pattern of increasing firstly and decreasing subsequently,and the blood stasis syn-drome of metabolism-related chronic osteopathy shows a pattern of decreasing firstly and increasing subsequently.On the whole,the blood stasis syndrome of chronic osteopathy presents a pattern of increasing at first and then decreasing.
万方数据
维普
