TCM syndrome types and clinical medication rules for lower limb swelling after primary total knee arthroplasty:a data mining-based analysis
Objective:To analyze the TCM syndrome types and medication rules for lower limb swelling following primary total knee ar-throplasty(TK A).Methods:The articles concerning TCM treatment of lower limb swelling after TKA included from database's inception to February 2024 were retrieved from China National Knowledge Infrastructure,Vip Database,and Wanfang Database through computer.The eligible articles were screened according to the predefined inclusion and exclusion criteria,and the data were extracted from the included ar-ticles and then input into the Microsoft Office Excel 2019 software to build a database,based on which,the involved TCM syndrome types,prescriptions,prescription function classifications,Chinese herbs(CHs)and CHs function classifications were normalized and standardized,followed by frequency statistics.The selected high-frequency CHs were then subjected to cluster analysis and association rule analysis.Results:①Article retrieval and screening results.Two thousand one hundred and thirty-one articles were searched out.After screening,57 ones were included in the final analysis.②The TCM syndrome type.Seven TCM syndrome types were involved in the 57 included arti-cles,among which the qi-stagnation and blood-stasis syndrome,blood-stasis and water-retention syndrome,as well as qi-deficiency and blood-stasis syndrome appeared most frequently.③The prescription.Fifty-seven prescriptions were involved in the 57 included articles,in-cluding 43 blood-regulating formulas,8 blood-supplementing formulas(TCD),5 desiccating formulas,and 1 interior-warming formulas,among which the Taohong Siwu Tang(桃红四物汤),Shentong Zhuyu Tang(身痛逐瘀汤),and Fuyuan Huoxue Tang(复元活血汤)appeared most frequently.④The CHs.One hundred and fifteen CHs were involved in the 57 prescriptions,among which 32 ones(high-frequency CHs)displayed a occurrence frequency≥5,and the top 4 ones with high occurrence frequency were Angelicae Sinensis Radix(TCD),Chuanxiong Rhizoma,Carthami Flos(TCD),and Glycyrrhizae Radix et Rhizoma(TCD).Furthermore,sorted by efficacy,the blood-activating and stasis-resolving CHs,as well as deficiency-reinforcing CHs appeared most frequently.As revealed by the cluster analysis,the 32 high-frequency CHs were clustered into three categories,with 5 CHs into Category I,mainly the ones for activating blood and removing stasis,which were suitable for qi-stagnation and blood-stasis syndrome;6 CHs into Category Ⅱ,mainly the ones for reinforcing qi,nourishing blood and strengthening spleen,which were suitable for qi-deficiency and blood-stasis syndrome;and 21 CHs into Category Ⅲ,mainly the ones for diuresis,removing Dampness,expelling Phlegm,and reinforcing liver-kidney,which were suitable for liver-kidney deficiency syn-drome,as well as intermingled phlegm and blood stasis syndrome.In addition,with a support of 30％and a confidence of 90％,the associ-ation rule analysis on the 32 high-frequency CHs yielded 6 core CHs(Carthami Flos(TCD),Persicae Semen,Angelicae Sinensis Radix(TCD),Chuanxiong Rhizoma,Glycyrrhizae Radix et Rhizoma(TCD),Paeoniae Radix Rubra),involving 19 association rules,with Angeli-cae Sinensis Radix(TCD)-Persicae Semen-Carthami Flos(TCD)as the core herb combination.Conclusion:The common TCM syndromes are qi-stagnation and blood-stasis syndrome,blood-stasis and water-retention syndrome,as well as qi-deficiency and blood-stasis syndrome for lower limb swelling in patients who underwent primary TKA.The clinical medication are centred on the blood-activating and stasis-re-solving CHs,as well as the deficiency-reinforcing CHs.The Carthami Flos(TCD),Persicae Semen,Angelicae Sinensis Radix(TCD),Chuanxiong Rhizoma,Glycyrrhizae Radix et Rhizoma(TCD)and Paeoniae Radix Rubra are usually used as the core CHs,and Angelicae Sinensis Radix(TCD)-Persicae Semen-Carthami Flos(TCD)as the core herb combination in treating lower limb swelling after primary TKA.
万方数据
维普
