The causal relationships of inflammatory factors with ankylosing spondylitis and blood metabolites:a mende-lian randomization analysis
Objective:To explore the causal relationships of inflammatory factors with ankylosing spondylitis(AS)and blood metabo-lites.Methods:The genome-wide association study(GW AS)data about the expression levels of inflammatory factors and blood metabolite indicators(metabolite levels or metabolite ratios)were retrieved and extracted from the GW AS Catalog database,and that about AS from the FinnGen database.According to the instrumental variable screening criteria,the eligible single nucleotide polymorphism(SNP)loci for the expression levels of inflammatory factors were screened as the instrumental variable,and then a mendelian randomization(MR)analysis was conducted with AS as the outcome variable to assess the causality between the expression levels of inflammatory factors and AS,and the sen-sitivity was examined.Furthermore,another MR analysis was conducted by taking the SNP loci of the expression levels of inflammatory factor having a reliable causality with AS as the instrumental variable,and the blood metabolite indicators as the outcome variable to assess the causality between the expression levels of inflammatory factors and blood metabolite indicators,and the sensitivity was examined.Results:①The causality between the expression levels of inflammatory factors and AS.The expression levels of CD244,fibroblast growth factor(FGF)-23,FMS-like tyrosine kinase 3 ligand(FIt3L)and interleukin(IL)-7 exhibited a reliable causal relationship with AS,among which,the expression levels of CD244 and FIt3L showed a inverse causal relationship with AS,while the expression levels of FGF-23 and IL-7 presented a positive causal relationship with AS.②The causality between the expression levels of inflammatory factors and blood metabolite indicators.The expression levels of CD244,FGF-23,FIt3L and IL-7 exhibited a reliable causal relationship with 61,62,37 and 68 blood metabolite indicators,respectively.Conclusion:The expression levels of FGF-23,IL-7,CD244 and FIt3L exhibit a reliable causal relationship with AS,and they also have a reliable causal relationship with multiterm blood metabolite indicators,respectively,which pro-vides a reference for exploring the pathogenesis of AS and the potential drug targets in treating AS.
万方数据
维普
