首页|Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

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Pregnant and postnatal women are a high-risk population particularly prone to rapid progression to sepsis with significant morbidity and mortality worldwide.Moreover,severe maternal infections can have a serious detrimen-tal impact on neonates with almost 1 million neonatal deaths annually attributed to maternal infection or sepsis.In this review we discuss the susceptibility of pregnant women and their specific physiological and immunolog-ical adaptations that contribute to their vulnerability to sepsis,the implications for the neonate,as well as the issues with antimicrobial stewardship and the challenges this poses when attempting to reach a balance between clinical care and urgent treatment.Finally,we review advancements in the development of pregnancy-specific diagnostic and therapeutic approaches and how these can be used to optimize the care of pregnant women and neonates.

SepsisPregnancyImmunologyCardiovascularPersonalised medicineAntibiotic stewardship

Nishel M Shah、Esmita Charani、Damien Ming、Fook-Choe Cheah、Mark R Johnson

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Department of Metabolism,Digestion and Reproduction,Imperial College London,Chelsea and Westminster Hospital,London,UK

Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance,Imperial College London,London,UK

Division of Infectious Diseases and HIV Medicine,Department of Medicine,Groote Schuur Hospital,University of Cape Town,Cape Town,South Africa

Department of Infectious Diseases,Imperial College London,Chelsea and Westminster Hospital,London,UK

Department of Paediatrics,Faculty of Medicine,Universiti Kebangsaan Malaysia Medical Centre,Kuala Lumpur,Malaysia

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2024

10.1016/j.jointm.2023.07.006

重症医学(英文)

重症医学(英文)

ISSN：
年,卷(期)：2024.4(1)
  • 219