首页|TRPV1:The key bridge in neuroimmune interactions
TRPV1:The key bridge in neuroimmune interactions
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The nervous and immune systems are crucial in fighting infections and inflammation and in maintaining immune homeostasis.The immune and nervous systems are independent,yet tightly integrated and coordinated organi-zations.Numerous molecules and receptors play key roles in enabling communication between the two systems.Transient receptor potential vanilloid subfamily member 1(TRPV1)is a non-selective cation channel,recently shown to be widely expressed in the neuroimmune axis and implicated in neuropathic pain,autoimmune disor-ders,and immune cell function.TRPV1 is a key bridge in neuroimmune interactions,allowing for smooth and convenient communication between the two systems.Here,we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 involved.We suggest that TRPV1 provides new insights into the collaborative relationship between the nervous and im-mune systems,highlighting exciting opportunities for advanced therapeutic approaches to treating neurogenic inflammation and immune-mediated diseases.
TRPV1Neuroimmune interactionImmune systemNervous system
Jianwei Chen、Wenqian Sun、Youjia Zhu、Feng Zhao、Shuixiang Deng、Mi Tian、Yao Wang、Ye Gong
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Department of Critical Care Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China
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