Pathophysiological dynamics in the contact,coagulation,and complement systems during sepsis:Potential targets for nafamostat mesilate

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外文摘要：Sepsis is a life-threatening syndrome resulting from a dysregulated host response to infection.It is the primary cause of death in the intensive care unit,posing a substantial challenge to human health and medical resource allocation.The pathogenesis and pathophysiology of sepsis are complex.During its onset,pro-inflammatory and anti-inflammatory mechanisms engage in intricate interactions,possibly leading to hyperinflammation,immuno-suppression,and long-term immune disease.Of all critical outcomes,hyperinflammation is the main cause of early death among patients with sepsis.Therefore,early suppression of hyperinflammation may improve the progno-sis of these patients.Nafamostat mesilate is a serine protease inhibitor,which can inhibit the activation of the complement system,coagulation system,and contact system.In this review,we discuss the pathophysiological changes occurring in these systems during sepsis,and describe the possible targets of the serine protease inhibitor nafamostat mesilate in the treatment of this condition.

外文关键词：

SepsisNafamostatContact systemCoagulation systemComplement system

作者：

Qiaolan He、Yilin Wei、Yiqi Qian、Ming Zhong

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作者单位：

Department of Critical Care Medicine,Zhongshan Hospital,Fudan University,Shanghai,China

Shanghai Key Laboratory of Lung Inflammation and Injury,Shanghai,China

Shanghai Institute of Infectious Disease and Biosecurity,School of Public Health,Fudan University,Shanghai,China

基金：

National Natural Science Foundation of ChinaKey discipline of Shanghai's Threeyear Action Plan to Strengthen the construction of public health system(2023-2025)

项目编号：

82102287GWVI-11.1-14

出版年：

2024

DOI：

10.1016/j.jointm.2024.02.003

重症医学(英文)

ISSN：

年,卷(期)：2024.4(4)