首页|Development of Emulgel Delivery of Mupirocin for Treatment of Skin Infection
Development of Emulgel Delivery of Mupirocin for Treatment of Skin Infection
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Aim: To design controlled release topical delivery of mupirocin for the treatment of skin infection. Background: Mupirocin is an antibacterial drug. Mupirocin works to kill the bacteria, which include strains of Staphylococcus aureus and Streptococcus pyogenes. It is also used for the treatment of inflammation of a hair follicle. The half-life of mupirocin is only 20-40 min. It has very slight solubility in water. Patent literature had shown work on ointment, antibiotic composition, nasal and topical composition. Emulgel is a duel control release system for the topical delivery of hydrophobic drugs. Objective: The objective was to formulate emulgel with controlled delivery of mupirocin using Sepineo P 600. Methods: Soya oil, tween 80 and polyethylene glycol 400 (Oil:Surfactant:Cosurfactant) were used for emulsion formulation. Emulgel was optimized by 32 factorial design. Sepineo P 600 and hydroxy propyl methyl cellulose K4M were used as independent variables. Drug excipient compatibility analysis was carried out by FTIR, UV and DSC spectra. Emulgel was evaluated for its physical characterization, in vitro release, ex vivo release, antimicrobial and anti-inflammatory study.
Topicaldeliveryemulgelmupirocinskin infectionsepineo P 600.
Swati C. Jagdale Payal V. Kothekar
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School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, MIT Campus, Kothrud, Pune, MH
NSTL
