首页|Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα
Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα
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Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFa was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFα was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
neutrophilinterleukin-15TNFαapoptosisBcl-Xl
LIU Xiuping、XIONG Changyun、LI Chunhong、YANG Deguang
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College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China
2007
Journal of Huazhong University of Science and Technology. Medical sciences. 医学英德文版
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