首页|Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and ·NO bioavailability: Potential benefits to cardiovascular diseases

Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and ·NO bioavailability: Potential benefits to cardiovascular diseases

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  • NETL
  • NSTL
  • Elsevier
Oxidative stress plays an important part in the appearance and development of cardiovascular diseases. In this context, overproduction of reactive oxygen species leads to deregulation of metabolic pathways, such as cell proliferation or inflammation, which interferes with the homeostasis of vascular endothe-lium. Oxidative stress can decrease the bioavailability of nitric oxide (·NO) in vessels. This decrease is highly associated with endothelial dysfunction. The "French paradox" is a phenomenon that associates a diet rich in saturated fatty acids and a moderate consumption of wine to a low prevalence of cardiovascular diseases. During the past 10 years, the beneficial effects of wine on cardiovascular diseases have been attributed to the actions of resveratrol and other polyphenols. One of the mechanisms involved in these beneficial effects is the capacity of resveratrol and some other stilbene derivatives to maintain sufficient ·NO bioavailability in vascular endothelium. This review presents the latest findings on the molecular effects of resveratrol and other stilbene derivatives on the various actors that modulate ·NO bioavailability during oxidative stress.

cardiovascular diseaseendothelial dysfunctionnitric oxideoxidative stressresveratrol

Matthieu Frombaum、Solenn Le Clanche、Dominique Bonnefont-Rousselot、Didier Borderie

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EA 4466 Stress Cellulaire, Physiopathologie, Strategies nutritionnelles et therapeutiques innovantes, Universite Paris Descartes, Sorbonne Paris Cite, UFR des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75006 Paris, France

EA 4466 Stress Cellulaire, Physiopathologie, Strategies nutritionnelles et therapeutiques innovantes, Universite Paris Descartes, Sorbonne Paris Cite, UFR des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75006 Paris, France,Service de Biochimie Metabolique, Groupe Hospitalier Pitie-Salpetriere (AP-HP), Paris Cedex 13, France

EA 4466 Stress Cellulaire, Physiopathologie, Strategies nutritionnelles et therapeutiques innovantes, Universite Paris Descartes, Sorbonne Paris Cite, UFR des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75006 Paris, France,Laboratoire de Biochimie A, Hopital Cochin APHP, 27 rue du faubourg Saint Jacques, 75679 Paris Cedex 14, France

2012

10.1016/j.biochi.2011.11.001

Biochimie

Biochimie

SCI
ISSN：0300-9084
年,卷(期)：2012.94(2)
  • 57
  • 85