When a cell divides, a series of tightly regulated events are sequentially passed through to end up with two healthy daughter cells. A dysregulation of these steps such as an escape from cell cycle control checkpoints may lead to tumor formation. In recent years, it became increasingly clear that our 24-h internal clock also contributes to proper timing of cell cycle progression and likely acts as a tumor suppressor (1). Although epide-miological studies argue that chronic living against one's circadian clock increases the risk for cancer (2) and other diseases, the molecular mechanisms for circadian timing of the cell cycle are little understood.
Bert Maier、Achim Kramer
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Laboratory of Chronobiology, Charite Universitaetsmedizin Berlin, 10115 Berlin, Germany
2013
Proceedings of the National Academy of Sciences of the United States of America
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NSTL
