miR-122 is more than a shield for the hepatitis C virus genome

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外文摘要：Since the discovery in 2005 of the essential role of the liver-specific microRNA, miR-122, in HCV replication (1), the mechanism by which it stimulates this process has proved elusive. In PNAS, Li et al. demonstrate that miR-122 acts to shield the HCV genome against degradation by the cytosolic RNA exo-nuclease, Xrnl (2). Although this may be one way in which this microRNA promotes HCV replication, the authors also show that loss of Xrnl is not enough to promote miR-122 independent HCV replication, indicating that miR-122 exerts yet another function in the HCV lifecycle.

作者：

Adolfo Garcia-Sastre、Matthew J. Evans

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作者单位：

Departments of Microbiology and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029,Departments of Medicine, and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029,Departments of Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029

Departments of Microbiology and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029

出版年：

2013

Proceedings of the National Academy of Sciences of the United States of America

ISSN：0027-8424

年,卷(期)：2013.110(5)