Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity

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NETL
NSTL
Walter De Gruyter

外文摘要：Viburnum macrocephalum f. keteleeri, not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of V. macrocephalum f. keteleeri were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl acetate and n-butanol. Among the different fractions, the ethyl acetate fraction exhibited the highest alpha-glucosidase inhibitory activity, and its bioassay-guided fractionation led to the isolation and identification of six compounds including a new 8-O-4'-neolignan glycoside (1), categorized as a rare 7-deoxy skeleton, three previously undescribed phenolic glycosides (2-4), together with two known secondary metabolites (5, 6), which were found for the first time in Viburnum. Noticeably, compound 1 had almost the same intestinal alpha-glucosidase inhibitory activity as the positive control acarbose.

外文关键词：

alpha-glucosidase inhibitory activityAdoxaceaeextractivesneolignan glycosidephenolic glycosideViburnum macrocephalum f. keteleeri

作者：

Zhao, Chunchao、Chen, Jia、Shao, Jianhua、Shen, Jie、Xu, Xiaoqing、Li, Kehuan、Gu, Wenyan、Zhao, Min、Fan, Judi

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作者单位：

Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China

Yangzhou Univ, Jiangsu Key Lab Crop Genet & Physiol, Coinnovat Ctr Modern Prod Technol Grain Crops, Yangzhou 225009, Jiangsu, Peoples R China

Guizhou Med Univ, Sch Pharm, Guiyang 550004, Guizhou, Peoples R China

Yangzhou Univ, Minist Educ China, Joint Int Res Lab Agr & Agriprod Safety, Yangzhou 225009, Jiangsu, Peoples R China

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出版年：

2018

DOI：

10.1515/hf-2018-0081

Holzforschung

ISSN：0018-3830

年,卷(期)：2018.72(12)

被引量6
参考文献量25