首页|Lawesson's reagent promoted deoxygenation of azlactones for the syntheses of 2,4-disubstituted thiazoles

Lawesson's reagent promoted deoxygenation of azlactones for the syntheses of 2,4-disubstituted thiazoles

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  • Royal Soc Chemistry
Azlactones and thiazoles are common structural motifs and possess diverse applications. A new method for the efficient and straightforward syntheses of 2,4-disubstituted thiazoles from azlactones has been developed. The reaction proceeded via deoxygenation of azlactones by Lawesson's reagent without metal or external additives. A variety of 2,4-disubstituted thiazoles were synthesized with up to 92% yield. Furthermore, the importance of this methodology was also justified by a gram-scale synthesis.

Gaofeng Yin、Xiaodong Wang、Yuqing Wang、Tao Shi、Yaofu Zeng、Yuying Wang、Xue Peng、Zhen Wang

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School of Pharmacy, Lanzhou University, West Donggang Road. No. 199,Lanzhou 730000, China

School of Pharmaceutical Science, Hengyang Medical School,University of South China, West Changsheng Road. No. 28, Hengyang 421001,China

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

2022

10.1039/d2ob01939f

Organic & biomolecular chemistry

Organic & biomolecular chemistry

CCR
ISSN：1477-0520
年,卷(期)：2022.20(48)
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