首页|Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

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  • NSTL
  • Royal Soc Chemistry
Myxoprincomide, a secondary metabolite of the myxobacterium Myxococcus xanthus DK 1622, is synthesised for the first time. The central, unusual a-ketoamide is generated at the end of the synthesis to avoid side reactions during the synthesis of this rather reactive subunit. Nevertheless, the synthetic natural product is obtained as an isomeric mixture. Detailed analytical investigations show that the identical isomeric mixture is found in the isolated natural product.

Michael Kohr、Christine Walt、Jan Dastbaz、Rolf Mueller、Uli Kazmaier

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Organic Chemistry, Saarland University, D-66123 Saarbriicken, Germany

Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Pharmacy, Saarland University, D-66123 Saarbriicken, Germany

Organic Chemistry, Saarland University, D-66123 Saarbriicken, Germany, Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Pharmacy, Saarland University, D-66123 Saarbriicken, Germany

2022

10.1039/d2ob02021a

Organic & biomolecular chemistry

Organic & biomolecular chemistry

CCR
ISSN：1477-0520
年,卷(期)：2022.20(48)
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