首页|Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations

Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations

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  • NSTL
  • Elsevier
Microglial dysfunction has been reported in the valproic acid (VPA)-induced autism spectrum disorder (ASD) rat models. However, how does prenatal VPA exposure affect microglia remains to be elucidated. The triggering receptor expressed on myeloid cells 2 (TREM2) is revealed to be implicated in a range of microglia functions. However, reports on the association between TREM2 and VPA-induced ASD rat models are scarce. Our results showed that prenatal VPA exposure induced autistic-like behaviors, downregulated the levels of TREM2, up-regulated microglial activation, dysregulated microglial polarization, and altered synapse in offspring. TREM2 overexpression partly ameliorated microglia dysfunction and autistic-like behaviors in prenatal VPA-exposed rats. Our findings demonstrated that prenatally VPA exposure is likely to cause autistic-like behavior in the rat offspring via TREM2 down-regulation to affect the microglial activation, microglial polarization and synaptic pruning of microglia for the first time.

Autism spectrum disordersMicroglial activationMicroglial polarizationSynaptic pruningTriggering receptor expressed on myeloid cells 2Valproic acid

Lijuan Luo、Jie Chen、Qionghui Wu、Binlin Yuan、Chaoqun Hu、Ting Yang、Hua Wei、Tingyu Li

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Children's Nutrition Research Center, Children s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Ghild Development and Disorders, Chongqing, China

Children's Nutrition Research Center, Children s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Ghild Development and Disorders, Chongqing, China,Department of Child Health Care, Children's Hospital of Chongqing Medical University, Chongqing, China

2023

10.1016/j.etap.2023.104090

Environmental toxicology and pharmacology

Environmental toxicology and pharmacology

SCI
ISSN：1382-6689
年,卷(期)：2023.99(Apr.)
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