Effects of personal exposure to the oxidative potential of PM_(2.5) on oxidative stress biomarkers in pregnant women

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Elsevier

外文摘要：Oxidative stress is a prominent pathway for the health effects associated with fine particulate matter (PM_(2.5))exposure. Oxidative potential (OP) of PM has been associated to several health endpoints, but studies on itsimpact on biomarkers of oxidative stress remains insufficient. 300 pregnant women from the SEPAGES cohort(France) carried personal PM_(2.5) samplers for a week and OP was measured using ascorbic acid (AA) anddithiothreitol (DTT) assays, and normalized by 1) PM_(2.5) mass (Op_m) and 2) sampled air volume (Op_v). A pool ofthree urine spots collected on the 7th day of PM sampling was analyzed for biomarkers, namely 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and 8-isoprostaglandin-F2α (8-isoPGF2α). Associationswere investigated using adjusted multiple linear regressions. OP effects were additionally investigated bystratifying by median PM_(2.5) concentration (14 μg m~(-3)). In the main models, no association was observed with 8-isoPGF2α, nor MDA. An interquartile range (IQR) increase in OP_m~(AA) exposure was associated with increased 8-OHdG (percent change: 6.2 %; 95 % CI: 0.2 % to 12.6 %). In the stratified analysis, exposure to OP_m~(AA) wasassociated with 8-OHdG for participants exposed to low levels of PM_(2.5) (percent change: 11.4 %; 95 % CI: 3.3 %to 20.1 %), but not for those exposed to high levels (percent change: - 1.0 %; 95 % CI: - 10.6 % to 9.6 %).Associations for OP_m~(DTT) also followed a similar pattern (p-values for OP_m~(AA)-PM and OP_m~(DTT)-PM interaction termswere 0.12 and 0.11, respectively). Overall, our findings suggest that OP_m~(AA) may be associated with increased DNAoxidative damage. This association was not observed with PM_(2.5) mass concentration exposure. The effects ofOP_m~(AA) in 8-OHdG tended to be stronger at lower (below median) vs. higher concentrations of PM_(2.5). Furtherepidemiological, toxicological and aerosol research are needed to further investigate the OP_m~(AA) effects on 8-OHdGand the potential modifying effect of PM mass concentration on this association.

外文关键词：

Personal exposure8-Hydroxy-2-deoxyguanosineMalondialdehyde8-Iso-prostaglandin-F2αOP~(AA)OP~(DTT)

作者：

Anouk Marsal、Jean-Jacques Sauvain、Aurelien Thomas、Sarah Lyon-Caen、Lucille Joanna S. Borlaza、Claire Philippat、Jean-Luc Jaffrezo、Anne Boudier、Sophie Darfeuil、Rhabira Elazzouzi、Johanna Lepeule、Ryan Chartier、Sam Bayat、Remy Slama、Valerie Siroux、Gaeelle Uzu

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作者单位：

Univ. Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGE, 38000 Grenoble, France||Agence de l'environnement et de la Maitrise de l'Energie, 20, avenue du Gresille, BP 90406 49004 Angers Cedex 01, France

Department of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisante), University Lausanne, Lausanne, Switzerland

Faculty Unit of Toxicology, CURML, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland||Unit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Lausanne, Geneva, Switzerland

University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute forAdvanced Biosciences, 38000 Grenoble, France

Univ. Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGE, 38000 Grenoble, France

RTI International, Research Triangle Park, NC, USA

Department of Pulmonology and Physiology, CHU Grenoble Alpes, Grenoble, France||Univ. Grenoble Alpes, Inserm UA07 STROBE Laboratory, Grenoble, France

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出版年：

2024

DOI：

10.1016/j.scitotenv.2023.168475

Science of the Total Environment

EISCI

ISSN：0048-9697

年,卷(期)：2024.911(Feb.10)

被引量1
参考文献量69