Two sets of papers investigating the top-of-the-mind problems of today open this Journal of Management Information Systems (JMIS) issue that completes the 40th -anniversary volume of the Journal. The first set presents the results of the impactful research on the interaction between humans and artificial intelligence (AI). The current and coming generative AI generates optimism regarding the new levels of human accomplishment when assisted across their working and private lives. Its promise contains a quantum productivity growth, which can lift billions out of poverty and toward expanded horizons. More specific to the information-systems' (IS) concerns, the ability of the generative AI to generate software code leads directly to what we may call implicit development by the end users who are able to specify their needs in a natural language. As a general-purpose technology, the new AI also produces high levels of anxiety regarding the availability of employment and, beyond that, the very survival of the humans when facing AI. The work on the guardrails is clearly to be praised, if its effectiveness in the present geopolitical environment is to be questioned. The two papers opening the issue address, respectively, the role of AI in the competition and in the collaboration with people.