首页|Amsterdam University Medical Centers Reports Findings in Cardiovascular Diseases and Conditions (Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study)
Amsterdam University Medical Centers Reports Findings in Cardiovascular Diseases and Conditions (Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study)
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
Oxford Univ Press
New research on Cardiovascular Diseases and Conditions is the subject of a report. According to news originating from Amsterdam, Netherlands, by NewsRx correspondents, research stated, “Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVD). The composition and abundance of gut microbiota trophic networks differ between ethnicities.” Our news journalists obtained a quote from the research from Amsterdam University Medical Centers, “We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes. We included cross-sectional data from 3860 individuals without CVD history from six ethnicities living in the Amsterdam region participating in the prospective Healthy Life in Urban Setting (HELIUS) study. Genetic variants were genotyped, fecal gut microbiota were profiled and blood and anthropometric parameters were measured. A machine learning approach was used to assess the relationship between CVD risk (Framingham Score) and gut microbiota stratified by ethnicity. Potential causal relationships between gut microbiota composition and CVD were inferred by performing two sample Mendelian randomization with hard CVD events from the Pan-UK biobank and microbiome GWAS summary data from a subset of the HELIUS cohort (n = 4117). Microbial taxa identified to be associated with CVD by machine learning and Mendelian randomization were often ethnic specific, but some concordance across ethnicities was found. The microbes Akkermansia muciniphila and Ruminococcaceae UCG-002 were protective against ischemic heart disease in African Surinamese and Moroccans, respectively. We identified a strong inverse association between blood lipids, CVD risk and the combined abundance of the correlated microbes Christensenellaceae- Methanobrevibacter-Ruminococcaceae (CMR). The CMR cluster was also identified in two independent cohorts and the association with triglycerides was replicated. Certain gut microbes can have a potentially causal relationship with CVD events, with possible ethnic specific effects.”
AmsterdamNetherlandsEuropeCardiologyCardiovascularCardiovascular Diseases and ConditionsCardiovascular ResearchCyborgsEmerging TechnologiesGeneticsHealth and MedicineMachine LearningRisk and Prevention
NETL
NSTL
Oxford Univ Press
