首页|University College London (UCL) Institute of Ophthalmology Reports Findings in Machine Learning (Image processing and supervised machine learning for retinal microglia characterization in senescence)
University College London (UCL) Institute of Ophthalmology Reports Findings in Machine Learning (Image processing and supervised machine learning for retinal microglia characterization in senescence)
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New research on Machine Learning is the subject of a report. According to news reporting out of London, United Kingdom, by NewsRx editors, research stated, “The process of senescence impairs the function of cells and can ultimately be a key factor in the development of disease. With an aging population, senescence-related diseases are increasing in prevalence.” Our news journalists obtained a quote from the research from the University College London (UCL) Institute of Ophthalmology, “Therefore, understanding the mechanisms of cellular senescence within the central nervous system (CNS), including the retina, may yield new therapeutic pathways to slow or even prevent the development of neuro- and retinal degenerative diseases. One method of probing the changing functions of senescent retinal cells is to observe retinal microglial cells. Their morphological structure may change in response to their surrounding cellular environment. In this chapter, we show how microglial cells in the retina, which are implicated in aging and diseases of the CNS, can be identified, quantified, and classified into five distinct morphotypes using image processing and supervised machine learning algorithms. The process involves dissecting, staining, and mounting mouse retinas, before image capture via fluorescence microscopy. The resulting images can then be classified by morphotype using a support vector machine (SVM) we have recently described showing high accuracy. This SVM model uses shape metrics found to correspond with qualitative descriptions of the shape of each morphotype taken from existing literature. We encourage more objective and widespread use of methods of quantification such as this.”
LondonUnited KingdomEuropeCentral Nervous SystemCyborgsEmerging TechnologiesHealth and MedicineMachine LearningMicrogliaNeuroglia
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