首页|Affiliated Cancer Hospital and Institute of Guangzhou Medical University Reports Findings in Cervical Cancer (Machine Learning- Based Multiparametric Magnetic Resonance Imaging Radiomics Model for Preoperative Predicting the Deep Stromal ...)
Affiliated Cancer Hospital and Institute of Guangzhou Medical University Reports Findings in Cervical Cancer (Machine Learning- Based Multiparametric Magnetic Resonance Imaging Radiomics Model for Preoperative Predicting the Deep Stromal ...)
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New research on Oncology - Cervical Cancer is the subject of a report. According to news reporting out of Guangzhou, People’s Republic of China, by NewsRx editors, research stated, “Deep stromal invasion is an important pathological factor associated with the treatments and prognosis of cervical cancer patients. Accurate determination of deep stromal invasion before radical hysterectomy (RH) is of great value for early clinical treatment decision-making and improving the prognosis of these patients.” Financial support for this research came from National Natural Science Foundation of China. Our news journalists obtained a quote from the research from the Affiliated Cancer Hospital and Institute of Guangzhou Medical University, “Machine learning is gradually applied in the construction of clinical models to improve the accuracy of clinical diagnosis or prediction, but whether machine learning can improve the preoperative diagnosis accuracy of deep stromal invasion in patients with cervical cancer was still unclear. This cross-sectional study was to construct three preoperative diagnostic models for deep stromal invasion in patients with early cervical cancer based on clinical, radiomics, and clinical combined radiomics data using the machine learning method. We enrolled 229 patients with early cervical cancer receiving RH combined with pelvic lymph node dissection (PLND). The least absolute shrinkage and selection operator (LASSO) and the fivefold cross-validation were applied to screen out radiomics features. Univariate and multivariate logistic regression analyses were applied to identify clinical predictors. All subjects were divided into the training set (n = 160) and testing set (n = 69) at a ratio of 7:3. Three light gradient boosting machine (LightGBM) models were constructed in the training set and verified in the testing set. The radiomics features were statistically different between deep stromal invasion ＜1/3 group and deep stromal invasion 1/3 group. In the training set, the area under the curve (AUC) of the prediction model based on radiomics features was 0.951 (95% confidence interval (CI) 0.922-0.980), the AUC of the prediction model based on clinical predictors was 0.769 (95% CI 0.703-0.835), and the AUC of the prediction model based on radiomics features and clinical predictors was 0.969 (95% CI 0.947-0.990). The AUC of the prediction model based on radiomics features and clinical predictors was 0.914 (95% CI 0.848-0.980) in the testing set.”
GuangzhouPeople’s Republic of ChinaAsiaCancerCervical CancerCyborgsEmerging TechnologiesHealth and MedicineMachine LearningOncologyWomen’s Health
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