首页|'Sterile Protection Attachment For Tips Of Liquid-Handling Devices' in Patent Application Approval Process (USPTO 20240053373)
'Sterile Protection Attachment For Tips Of Liquid-Handling Devices' in Patent Application Approval Process (USPTO 20240053373)
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A patent application by the inventors Rix, Karl (Velbert, DE); Schillig, Christophe (Gossau ZH, CH); Schneider, Falk (Aachen, DE); Schuler, Kai (Hoffeld SG, CH); Selzer, Sebastian (Klosterneuburg, AT), filed on January 11, 2022, was made available online on February 15, 2024, according to news reporting originating from Washington, D.C., by NewsRx correspondents. This patent application is assigned to Eppendorf SE (Hamburg, Germany). The following quote was obtained by the news editors from the background information supplied by the inventors: "Autosamplers or pipetting robots, which automate the process of sample preparation and distribution to a downstream and usually sequential analysis, can be typically found on the market. The samples are usually already available in suitable miniature vessels. Bioprocesses commonly require that samples be repeatedly withdrawn as sterilely as possible from the bioreactor during the cultivation therein and be stored temporarily or transferred directly (online) to an analysis. Since parallel operation of multiple bioreactors is increasingly being carried out, the sampling from multiple reactors is to be done via a sampling system (often in the form of a multiplexer). This requires compliance with usually increased sterile requirements, especially in the case of withdrawal from the bioreactor. The possibility of contamination from the environment or between different bioreactors (cross-contamination) must be reliably prevented. Online sampling systems can be in the form of hose-guided closed systems comprising pumps and valves or in the form of liquid-handling systems comprising reusable glass syringes or disposable plastic tips. In closed systems, the contamination or cleaning of the hoses, or the dead volume, is often a problem. Liquid-handling systems can, moreover, also be used for adding substances to multiple bioreactors during cultivation in a specific manner (e.g., on the basis of an evaluated analytical result for a previously withdrawn sample). In this case too, more reliable prevention of contamination is absolutely necessary.
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