首页|University of Queensland Reports Findings in Machine Learning (ParaPET: non-invasive deep learning method for direct parametric brain PET reconstruction using histoimages)
University of Queensland Reports Findings in Machine Learning (ParaPET: non-invasive deep learning method for direct parametric brain PET reconstruction using histoimages)
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NETL
NSTL
Springer Nature
New research on Machine Learning is the subject of a report. According to news originating from Brisbane, Australia, by NewsRx correspondents, research stated, “The indirect method for generating parametric images in positron emission tomography (PET) involves the acquisition and reconstruction of dynamic images and temporal modelling of tissue activity given a measured arterial input function. This approach is not robust, as noise in each dynamic image leads to a degradation in parameter estimation.” Financial support for this research came from Australian Research Council Training Centre for Innovation in Biomedical Imaging Technology. Our news journalists obtained a quote from the research from the University of Queensland, “Direct methods incorporate into the image reconstruction step both the kinetic and noise models, leading to improved parametric images. These methods require extensive computational time and large computing resources. Machine learning methods have demonstrated significant potential in overcoming these challenges. But they are limited by the requirement of a paired training dataset. A further challenge within the existing framework is the use of state-of-the-art arterial input function estimation via temporal arterial blood sampling, which is an invasive procedure, or an additional magnetic resonance imaging (MRI) scan for selecting a region where arterial blood signal can be measured from the PET image. We propose a novel machine learning approach for reconstructing high-quality parametric brain images from histoimages produced from time-of-flight PET data without requiring invasive arterial sampling, an MRI scan, or paired training data from standard field-of-view scanners. The proposed is tested on a simulated phantom and five oncological subjects undergoing an 18F-FDG-PET scan of the brain using Siemens Biograph Vision Quadra. Kinetic parameters set in the brain phantom correlated strongly with the estimated parameters (K, k and k, Pearson correlation coefficient of 0.91, 0.92 and 0.93) and a mean squared error of less than 0.0004. In addition, our method significantly outperforms (p <0.05, paired t-test) the conventional nonlinear least squares method in terms of contrast-to-noise ratio. At last, the proposed method was found to be 37% faster than the conventional method. We proposed a direct non-invasive DL-based reconstruction method and produced high-quality parametric maps of the brain. The use of histoimages holds promising potential for enhancing the estimation of parametric images, an area that has not been extensively explored thus far.”
BrisbaneAustraliaAustralia and New ZealandCyborgsEmerging TechnologiesMachine Learning
NETL
NSTL
Springer Nature
