首页|Qiqihar Medical University Reports Findings in Obsessive-Compulsive Disorder (Tw o multimodal neuroimaging subtypes of obsessive-compulsive disorder disclosed by semi-supervised machine learning)
Qiqihar Medical University Reports Findings in Obsessive-Compulsive Disorder (Tw o multimodal neuroimaging subtypes of obsessive-compulsive disorder disclosed by semi-supervised machine learning)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Mental Health Diseases and Conditions - Obsessive-Compulsive Disorder is the subject of a report. Acco rding to news originating from Heilongjiang, People's Republic of China, by News Rx correspondents, research stated, "Obsessive-compulsive disorder (OCD) is a hi ghly heterogeneous mental condition with a diverse symptom. Existing studies cla ssified OCD on the basis of conventional phenomenology-based taxonomy ignoring t he fact that the same subtype identified in accordance with clinical symptom may have different mechanisms and treatment responses." Our news journalists obtained a quote from the research from Qiqihar Medical Uni versity, "This research involved 50 medicine-free patients with OCD and 50 match ed healthy controls (HCs). All the participants were subjected to structural and functional magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) and amplitude of low frequency fluctuation (ALFF) were used to evaluate gray matter volume (GMV) and spontaneous neuronal activities at rest respectively. Similarit y network fusion (SNF) was utilized to integrate GMVs and spontaneous neuronal a ctivities, and heterogeneity by discriminant analysis was applied to characteris e OCD subtypes. Two OCD subtypes were identified: Subtype 1 exhibited decreased GMVs (i.e., left inferior temporal gyrus, right supplementary motor area and rig ht lingual gyrus) and increased ALFF value (i.e., right orbitofrontal cortex), w hereas subtype 2 exhibited increased GMVs (i.e., left cuneus, right precentral g yrus, left postcentral gyrus and left hippocampus) and decreased ALFF value (i.e ., right caudate nucleus). Furthermore, the altered GMVs was negatively correlat ed with abnormal ALFF values in both subtype 1 and 2. This study requires furthe r validation via a larger, independent dataset and should consider the potential influences of psychotropic medication on OCD patients' brain activities."
HeilongjiangPeople's Republic of ChinaAsiaCyborgsEmerging TechnologiesHealth and MedicineMachine LearningM ental Health Diseases and ConditionsNeuroimagingObsessive-Compulsive Disorde r
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