首页|Third Affiliated Hospital of Southern Medical University Reports Findings in Mac hine Learning (Analysis and validation of potential ICD-related biomarkers in de velopment of myopia using machine learning)

Third Affiliated Hospital of Southern Medical University Reports Findings in Mac hine Learning (Analysis and validation of potential ICD-related biomarkers in de velopment of myopia using machine learning)

扫码查看
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Machine Learning is th e subject of a report. According to news reporting originating in Guangzhou, Peo ple's Republic of China, by NewsRx journalists, research stated, "We aimed to id entify and verify potential biomarkers in the development of myopia associated w ith immunogenic cell death (ICD). We download high myopia (HM) dataset GSE136701 from Gene Expression Omnibus." The news reporters obtained a quote from the research from the Third Affiliated Hospital of Southern Medical University, "Differentially expressed genes in HM w ere identified to overlapped with ICD-related genes. Least absolute shrinkage an d selection operator were used to select the Hub genes. Furthermore, the correla tion between the hub genes and immune infiltration, immune response activities, and hub genes Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis w as investigated using Spearman's rank correlation. Prediction of the miRNAs upst ream of the Hub genes was based on the TargetScan database. We used guinea pig l ens-induced myopia model's scleral tissues performed quantitative realtime poly merase chain reaction. We identified overlapped with ICD-related genes (LY96, IL 1A, IL33, and AGER) and two genes (LY96 and AGER) as hub genes. Single sample ge ne set enrichment analysis and Spearman's rank correlation revealed that hub gen e expression levels in HM were significantly correlated with the infiltration pe rcentages of CD56dim natural killer cells, macrophages, immature B cells, and th e immune response activities of APC co-stimulation and Kyoto Encyclopedia of Gen es and Genomes pathways, such as terpenoid backbone biosynthesis, aminoacyl-trna biosynthesis, Huntington's disease, oxidative phosphorylation; there were a few additional signaling pathways compared to normal samples. Additionally, several miRNA were predicted as upstream regulators of LY96 and AGER. LY96 was identifi ed as a significantly differentially expressed biomarker in myopia guinea pig's scleral tissues, as verified by qPCR. LY96 was identified and verified as a ICD- related potential myopia biomarker."

GuangzhouPeople's Republic of ChinaA siaCyborgsEmerging TechnologiesGeneticsMachine Learning

2024

Robotics & Machine Learning Daily News

Robotics & Machine Learning Daily News

ISSN:
年,卷(期):2024.(Mar.11)