首页|First Affiliated Hospital of Jinan University Reports Findings in Prostate Cance r (Identification of a 9-gene signature to enhance biochemical recurrence predic tion in primary prostate cancer:A benchmarking study using ten machine learning ...)
First Affiliated Hospital of Jinan University Reports Findings in Prostate Cance r (Identification of a 9-gene signature to enhance biochemical recurrence predic tion in primary prostate cancer:A benchmarking study using ten machine learning ...)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Prostate Ca ncer is the subject of a report.According to news reporting originating in Guan gdong,People's Republic of China,by NewsRx journalists,research stated,"Pros tate cancer (PCa) is a prevalent malignancy among men worldwide,and biochemical recurrence (BCR) after radical prostatectomy (RP) is a critical turning point c ommonly used to guide the development of treatment strategies for primary PCa.H owever,the clinical parameters currently in use are inadequate for precise risk stratification and informing treatment choice." The news reporters obtained a quote from the research from the First Affiliated Hospital of Jinan University,"To address this issue,we conducted a study that collected transcriptomic data and clinical information from 1662 primary PCa pat ients across 12 multicenter cohorts globally.We leveraged 101 algorithm combina tions that consisted of 10 machine learning methods to develop and validate a 9- gene signature,named BCR SCR,for predicting the risk of BCR after RP.Our resu lts demonstrated that BCR SCR generally outperformed 102 published prognostic si gnatures.We further established the clinical significance of these nine genes i n PCa progression at the protein level through immunohistochemistry on Tissue Mi croarray (TMA).Moreover,our data showed that patients with higher BCR SCR tend ed to have higher rates of BCR and distant metastasis after radical radiotherapy .Through drug target prediction analysis,we identified nine potential therapeu tic agents for patients with high BCR SCR."
GuangdongPeople's Republic of ChinaA siaBiochemicalsBiochemistryCancerChemicalsCyborgsEmerging Technologi esGeneticsHealth and MedicineMachine LearningOncologyProstate CancerProstatic NeoplasmsRadical ProstatectomyRisk and PreventionSurgery