Abstract
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Cardiovascular Disease s and Conditions - Hypertension is the subject of a report.According to news re porting from Johannesburg,South Africa,by NewsRx journalists,research stated,"Hypertension is an important public health priority with a high prevalence in Africa.It is also an independent risk factor for kidney outcomes." The news correspondents obtained a quote from the research from the University o f the Witwatersrand,"We aimed to identify potential proteins and pathways invol ved in hypertension-associated albuminuria by assessing urinary proteomic profil es in black South African participants with combined hypertension and albuminuri a compared to those who have neither condition.The study included 24 South Afri can cases with both hypertension and albuminuria and 49 control participants who had neither condition.Protein was extracted from urine samples and analysed us ing ultra-high-performance liquid chromatography coupled with mass spectrometry.Data were generated using data-independent acquisition (DIA) and processed usin g Spectronaut? 15.Statistical and functional data annotation were performed on Perseus and Cytoscape to identify and annotate differentially abundant proteins.Machine learning was applied to the dataset using the OmicLearn platform.Overa ll,a mean of 1,225 and 915 proteins were quantified in the control and case gro ups,respectively.Three hundred and thirty-two differentially abundant proteins were constructed into a network.Pathways associated with these differentially abundant proteins included the immune system (q-value [false discovery rate] = 1.4 ? 10),innate immune system (q = 1.1 ? 10),extracellular matrix (ECM) organisation (q = 0.03) and activation of matrix metalloproteinases (q = 0.04).Proteins with high disease scores (76-100% confidence) for both hypertension and chronic kidney disease included angiotensi nogen (AGT),albumin (ALB),apolipoprotein L1 (APOL1),and uromodulin (UMOD).A machine learning approach was able to identify a set of 20 proteins,differentia ting between cases and controls."
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