首页|Nanjing Medical University Reports Findings in Colon Cancer (Deciphering alterna tive splicing events and their therapeutic implications in colorectal Cancer)
Nanjing Medical University Reports Findings in Colon Cancer (Deciphering alterna tive splicing events and their therapeutic implications in colorectal Cancer)
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Colon Cance r is the subject of a report. According to news reporting originating from Jiang su,People's Republic of China,by NewsRx correspondents,research stated,"Colo rectal cancer (CRC) is one of the most common malignant tumors with complex mole cular regulatory mechanisms. Alternative splicing (AS),a fundamental regulatory process of gene expression,plays an important role in the occurrence and devel opment of CRC." Our news editors obtained a quote from the research from Nanjing Medical Univers ity,"This study analyzed AS Percent Spliced In (PSI) values from 49 pairs of CR C and normal samples in the TCGA SpliceSeq database. Using Lasso and SVM,AS fea tures that can differentiate colorectal cancer from normal were screened. Univar iate COX regression analysis identified prognosis-related AS events. A risk mode l was constructed and validated using machine learning,Kaplan-Meier analysis,a nd Decision Curve Analysis. The regulatory effect of protein arginine methyltran sferase 5 (PRMT5) on poly(RC) binding protein 1 (PCBP1) was verified by immunopr ecipitation experiments,and the effect of PCBP1 on the AS of Obscurin (OBSCN) w as verified by PCR. Five AS events,including HNF4A.59461.AP and HNF4A.59462.AP,were identified,which can distinguish CRC from normal tissue. A machine learni ng model using 21 key AS events accurately predicted CRC prognosis. High-risk pa tients had significantly shorter survival times. PRMT5 was found to regulate PCB P1 function and then influence OBSCN AS,which may drive CRC progression. The st udy concluded that some AS events is significantly different in CRC and normal t issues,and some of these AS events are related to the prognosis of CRC."
JiangsuPeople's Republic of ChinaAsi aCancerColon CancerColorectal ResearchCyborgsDrugs and TherapiesEmer ging TechnologiesGastroenterologyHealth and MedicineMachine LearningOnco logy
NETL
NSTL
