首页|Barts Heart Centre Reports Findings in Hypertrophic Cardiomyopathy (Electrophysi ological Characterization of Subclinical and Overt Hypertrophic Cardiomyopathy b y Magnetic Resonance Imaging-Guided Electrocardiography)
Barts Heart Centre Reports Findings in Hypertrophic Cardiomyopathy (Electrophysi ological Characterization of Subclinical and Overt Hypertrophic Cardiomyopathy b y Magnetic Resonance Imaging-Guided Electrocardiography)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Heart Disorders and Di seases - Hypertrophic Cardiomyopathy is the subject of a report. According to ne ws reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Ventricular arrhythmia in hypertrophic cardiomyopathy (HCM) re lates to adverse structural change and genetic status. Cardiovascular magnetic r esonance (CMR)-guided electrocardiographic imaging (ECGI) noninvasively maps car diac structural and electrophysiological (EP) properties." Our news editors obtained a quote from the research from Barts Heart Centre, "Th e purpose of this study was to establish whether in subclinical HCM (genotype [G]+ left ventricular hypertrophy [LVH] -), ECGI detects early EP abnormality, and in overt HCM, whether the EP substrat e relates to genetic status (G+/G-LVH+) and structural phenotype. This was a pro spective 211-participant CMR-ECGI multicenter study of 70 G+LVH-, 104 LVH+ (51 G +/53 G-), and 37 healthy volunteers (HVs). Local activation time (AT), corrected repolarization time, corrected activation-recovery interval, spatial gradients (G/G), and signal fractionation were derived from 1,000 epicardial sites per par ticipant. Maximal wall thickness and scar burden were derived from CMR. A suppor t vector machine was built to discriminate G+LVH- from HV and low-risk HCM from those with intermediate/high-risk score or nonsustained ventricular tachycardia. Compared with HV, subclinical HCM showed mean AT prolongation (P = 0.008) even with normal 12-lead electrocardiograms (ECGs) (P = 0.009), and repolarization wa s more spatially heterogenous (G: P = 0.005) (23% had normal ECGs) . Corrected activation-recovery interval was prolonged in overt vs subclinical H CM (P <0.001). Mean AT was associated with maximal wall th ickness; spatial conduction heterogeneity (G) and fractionation were associated with scar (all P<0.05), and G+LVH+ had more fractionation than G-LVH+ (P = 0.002). The support vector machine discriminated subclinical HC M from HV (10-fold cross-validation accuracy 80% [95% CI: 73%-85%]) and identified patients at higher risk of sudden cardiac death (accuracy 82% [95% CI: 78%-86%] ). In the absence of LVH or 12-lead ECG abnormalities, HCM sarcomere gene mutati on carriers express an aberrant EP phenotype detected by ECGI."Keywords for this news article include: London, United Kingdom, Europe, Cardiolo gy, Cardiomyopathies, Cardiovascular, Cardiovascular Diseases and Conditions, Di agnosis, Diagnostic Techniques and Procedures, Electrocardiography, Emerging Tec hnologies, Genetics, Health and Medicine, Heart Disease, Heart Disorders and Dis eases, Heart Function Tests, Hypertrophic Cardiomyopathy, Machine Learning, Magn etic Resonance, Risk and Prevention, Sudden Cardiac Death, Support Vector Machin es, Vector Machines
LondonUnited KingdomEuropeCardiolo gyCardiomyopathiesCardiovascularCardiovascular Diseases and ConditionsDi agnosisDiagnostic Techniques and ProceduresElectrocardiographyEmerging Tec hnologiesGeneticsHealth and MedicineHeart DiseaseHeart Disorders and Dis easesHeart Function TestsHypertrophic CardiomyopathyMachine LearningMagn etic ResonanceRisk and PreventionSudden Cardiac DeathSupport Vector Machin esVector Machines
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