Abstract
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Machine Learning is th e subject of a report. According to news reporting from Jinan, People's Republic of China, by NewsRx journalists, research stated, "Maren Runchang pill (MRRCP) is a Chinese patent medicine used to treat constipation in clinics. It has multi -component and multi-target characteristics, and there is an urgent need to scre en markers to ensure its quality." Funders for this research include Key Technology Research and Development Progra m of Shandong Province, Qilu University of Technology, Agriculture Research Syst em of China. The news correspondents obtained a quote from the research from the Qilu Univers ity of Technology (Shandong Academy of Sciences), "The aim of this study was to screen quality markers of MRRCP based on a ‘differential compounds-bioactivity' strategy using machine learning and network pharmacology to ensure the effective ness and stability of MRRCP. In this study, UPLC-Q-TOF-MS/MS was used to identif y chemical compounds in MRRCP and machine learning algorithms were applied to sc reen differential compounds. The quality markers were further screened by networ k pharmacology. Meanwhile, molecular docking was used to verify the screening re sults of machine learning and network pharmacology. A total of 28 constituents i n MRRCP were identified, and four differential compounds were screened by machin e learning algorithms. Subsequently, a total of two quality markers (rutin and r ubiadin) in MRRCP. Additionally, the molecular docking results showed that quali ty markers could spontaneously bind to core targets. This study provides a refer ence for improving the quality evaluation method of MRRCP to ensure its quality. "
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