首页|LMU University Hospital Reports Findings in Prostatectomy [Assessing Stress Induced by Fluid Shifts and Reduced Cerebral Clearance during Robotic-Assisted Laparoscopic Radical Prostatectomy under Trendelenburg Positioning (UroTreND Study)]
LMU University Hospital Reports Findings in Prostatectomy [Assessing Stress Induced by Fluid Shifts and Reduced Cerebral Clearance during Robotic-Assisted Laparoscopic Radical Prostatectomy under Trendelenburg Positioning (UroTreND Study)]
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By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News - New research on Surgery - Prostatectom y is the subject of a report. According to news reporting originating in Munich, Germany, by NewsRx journalists, research stated, “In additionto general anesth esia and mechanical ventilation, robotic-assisted laparoscopic radical prostatec tomy(RALP) necessitates maintaining a capnoperitoneum and placing the patient i n a pronounced downwardtilt (Trendelenburg position). While the effects of the resulting fluid shift on the cardiovascular systemseem to be modest and well to lerated, the effects on the brain and the blood-brain barrier have not beenthor oughly investigated.”The news reporters obtained a quote from the research from LMU University Hospit al, “Previous studiesindicated that select patients showed an increase in the o ptic nerve sheath diameter (ONSD), detectedby ultrasound during RALP, which sug gests an elevation in intracranial pressure. We hypothesize thatthe intraoperat ive fluid shift results in endothelial dysfunction and reduced cerebral clearanc e, potentiallyleading to transient neuronal damage. This prospective, monocentr ic, non-randomized, controlled clinicaltrial will compare RALP to conventional open radical prostatectomy (control group) in a total of 50subjects. The primar y endpoint will be the perioperative concentration of neurofilament light chain (NfL)in blood using single-molecule array (SiMoA) as a measure for neuronal dam age. As secondary endpoints,various other markers for endothelial function, inf lammation, and neuronal damage as well as the ONSDwill be assessed. Perioperati ve stress will be evaluated by questionnaires and stress hormone levels insaliv a samples. Furthermore, the subjects will participate in functional tests to eva luate neurocognitivefunction. Each subject will be followed up until discharge.”
MunichGermanyEuropeEmerging Techno logiesHealth and MedicineMachine LearningProstatectomyRoboticsRobotsSurgery
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