Abstract
Reporters obtained the following quote from the background information supplied by the inventors: “Histotripsy, or pulsed ultrasound cavitation therapy, is a te chnology where extremely short, intense bursts of acoustic energy induce control led cavitation (microbubble formation) within the focal volume. The vigorous exp ansion and collapse of these microbubbles mechanically homogenizes cells and tis sue structures within the focal volume. This is a very different end result than the coagulative necrosis characteristic of thermal ablation. To operate within a non-thermal, Histotripsy realm; it is necessary to deliver acoustic energy in the form of high amplitude acoustic pulses with low duty cycle.
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