Abstract
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Prostate Ca ncer is the subject of a report. According to news reporting originating from Fl orence, Italy, by NewsRx correspondents, research stated, "We sought to investig ate whether surgical delay may be associated with pathological upstaging in pati ents treated with robot assisted radical prostatectomy (RARP) for localized and locally advanced prostate cancer (PCa). Consecutive firstly-diagnosed PCa patien ts starting from March 2020 have been enrolled." Our news editors obtained a quote from the research from the University of Flore nce, "All the patients were categorized according to EAU risk categories for PCa risk. Uni- and multivariate analysis were fitted to explore clinical and surgic al predictors of pathological upstaging to locally advanced disease (pT3/pT4 - p N1 disease). Overall 2017 patients entered the study. Median age at surgery was 68 (IQR 63-73) years. Overall low risk, intermediate risk, localized high risk a nd locally advanced disease were recorded in 368 (18.2 %), 1071 (53 .1 %), 388 (19.2 %) and 190 (9.4 %), resp ectively. Median time from to diagnosis to treatment was 51 (IQR 29-70) days. Ti me to surgery was 56 (IQR 32-75), 52 (IQR 30-70), 45 (IQR 24-60) and 41 (IQR 22- 57) days for localized low, intermediate and high risk and locally advanced dise ase, respectively. Considering 1827 patients with localized PCa, at multivariate analysis ISUP grade group 4 on prostate biopsy (HR: 1.30; 95 % CI 1.07-1.86; p = 0.02) and surgical delay only in localized high-risk disease (HR : 1.02; 95 % CI 1.01-1.54; p = 0.02) were confirmed as independent predictors of pathological upstaging to pT3-T4/pN1 disease at final histopathol ogical examination."
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