摘要
记者从发明人提供的背景信息中获得了以下引文：“分析和表征生物和生化材料的材料和系统的进步导致了对生命、健康、疾病和治疗机制的更好理解。例如，基因组测序可用于获得诊断、预测、生物技术、生物医学信息。”独特的核酸序列的检测对于许多工作至关重要，包括鉴定微生物、诊断感染性疾病、检测基因异常、识别与各种癌症相关的生物标记物、评估对特定疾病的遗传易感性以及评估患者对医疗治疗的反应。基于寡核苷酸的DNA(DNA)微阵列可能成为大规模并行分析基因组序列和基因表达的有用工具。目前DNA微阵列的应用包括转录过程的全局分析、肿瘤临床过程的评估和药物靶点的快速发现。这些基于寡核苷酸的DNA微阵列的制造可能需要可靠的固体表面化学合成。
Abstract
Reporters obtained the following quote from the background information supplied by the inventors: “Advances in materials and systems to analyze and characterize biological and biochemical materials have led to improved understanding of the mechanisms of life, health, disease and treatment. For example, genomic sequenci ng can be used to obtain biomedical information in diagnostics, prognostics, bio technology, and forensics. The detection of distinctive nucleic acid sequences i s critical to many endeavors including identifying microorganisms, diagnosing in fectious diseases, detecting genetic abnormalities, identifying biomarker associ ated with various cancers, rating genetic susceptibility to selected diseases, a nd evaluating patient’s response to medical treatments. Accordingly, oligonucleo tide-based deoxyribonucleic acid (DNA) microarrays may become a useful tool for large-scale parallel analyses of genome sequence and gene expression. Current ap plications of DNA microarrays include global analyses of transcriptional process es, evaluation of clinical course of tumors, and accelerated discovery of drug t argets. Manufacturing these oligonucleotide-based DNA microarrays may need relia ble chemical synthesis on a solid surface.”
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