First Affiliated Hospital of Harbin Medical University Reports Findings in Adeno carcinoma (Evaluating the predictive value of angiogenesis-related genes for pro gnosis and immunotherapy response in prostate adenocarcinoma using machine learn ing ...)
First Affiliated Hospital of Harbin Medical University Reports Findings in Adeno carcinoma (Evaluating the predictive value of angiogenesis-related genes for pro gnosis and immunotherapy response in prostate adenocarcinoma using machine learn ing ...)
By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Adenocarcin oma is the subject of a report. According to news reporting originating in Harbi n, People's Republic of China, by NewsRx journalists, research stated, "Angiogen esis, the process of forming new blood vessels from pre-existing ones, plays a c rucial role in the development and advancement of cancer. Although blocking angi ogenesis has shown success in treating different types of solid tumors, its rele vance in prostate adenocarcinoma (PRAD) has not been thoroughly investigated." The news reporters obtained a quote from the research from the First Affiliated Hospital of Harbin Medical University, "This study utilized the WGCNA method to identify angiogenesis-related genes and assessed their diagnostic and prognostic value in patients with PRAD through cluster analysis. A diagnostic model was co nstructed using multiple machine learning techniques, while a prognostic model w as developed employing the LASSO algorithm, underscoring the relevance of angiog enesis-related genes in PRAD. Further analysis identified MAP7D3 as the most sig nificant prognostic gene among angiogenesisrelated genes using multivariate Cox regression analysis and various machine learning algorithms. The study also inv estigated the correlation between MAP7D3 and immune infiltration as well as drug sensitivity in PRAD. Molecular docking analysis was conducted to assess the bin ding affinity of MAP7D3 to angiogenic drugs. Immunohistochemistry analysis of 60 PRAD tissue samples confirmed the expression and prognostic value of MAP7D3. Ov erall, the study identified 10 key angiogenesis-related genes through WGCNA and demonstrated their potential prognostic and immune-related implications in PRAD patients. MAP7D3 is found to be closely associated with the prognosis of PRAD an d its response to immunotherapy. Through molecular docking studies, it was revea led that MAP7D3 exhibits a high binding affinity to angiogenic drugs. Furthermor e, experimental data confirmed the upregulation of MAP7D3 in PRAD, correlating w ith a poorer prognosis."
Key words
Harbin/People's Republic of China/Asia/Adenocarcinoma/Angiogenesis/Cancer/Cyborgs/Drugs and Therapies/Emerging T echnologies/Genetics/Health and Medicine/Immunology/Immunotherapy/Machine L earning/Oncology
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