首页|Recent Findings from Albert Einstein College of Medicine Provides New Insights i nto Artificial Intelligence (Encoding the Space of Protein-protein Binding Inter faces By Artificial Intelligence)
Recent Findings from Albert Einstein College of Medicine Provides New Insights i nto Artificial Intelligence (Encoding the Space of Protein-protein Binding Inter faces By Artificial Intelligence)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-Investigators publish new report on Ar tificial Intelligence. According to news reporting out of Bronx, New York, by Ne wsRx editors, research stated, "The physical interactions between proteins are l argely determined by the structural properties at their binding interfaces. It w as found that the binding interfaces in distinctive protein complexes are highly similar." Funders for this research include National Institutes of Health (NIH) - USA, Alb ert Einstein College of Medicine. Our news journalists obtained a quote from the research from the Albert Einstein College of Medicine, "The structural properties underlying different binding in terfaces could be further captured by artificial intelligence. In order to test this hypothesis, we broke protein-protein binding interfaces into pairs of inter acting fragments. We employed a generative model to encode these interface fragm ent pairs in a lowdimensional latent space. After training, new conformations o f interface fragment pairs were generated. We found that, by only using a small number of interface fragment pairs that were generated by artificial intelligenc e, we were able to guide the assembly of protein complexes into their native con formations. These results demonstrate that the conformational space of fragment pairs at protein-protein binding interfaces is highly degenerate. Features in th is degenerate space can be well characterized by artificial intelligence."
BronxNew YorkUnited StatesNorth an d Central AmericaArtificial IntelligenceEmerging TechnologiesMachine Learn ingAlbert Einstein College of Medicine
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