首页|Affiliated Hospital of Nantong University Reports Findings in Inflammatory Bowel Disease (The shared circulating diagnostic biomarkers and molecular mechanisms of systemic lupus erythematosus and inflammatory bowel disease)
Affiliated Hospital of Nantong University Reports Findings in Inflammatory Bowel Disease (The shared circulating diagnostic biomarkers and molecular mechanisms of systemic lupus erythematosus and inflammatory bowel disease)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – New research on Digestive System Disea ses and Conditions - Inflammatory Bowel Disease is the subject of a report. Acco rding to news reporting originating from Nantong, People’s Republic of China, by NewsRx correspondents, research stated, “Systemic lupus erythematosus (SLE) is a multi-organ chronic autoimmune disease. Inflammatory bowel disease (IBD) is a common chronic inflammatory disease of the gastrointestinal tract.” Our news editors obtained a quote from the research from the Affiliated Hospital of Nantong University, “Previous studies have shown that SLE and IBD share comm on pathogenic pathways and genetic susceptibility, but the specific pathogenic m echanisms remain unclear. The datasets of SLE and IBD were downloaded from the G ene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identif ied using the Limma package. Weighted gene coexpression network analysis (WGCNA) was used to determine co-expression modules related to SLE and IBD. Pathway enr ichment was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes a nd Genomes (KEGG) analysis for co-driver genes. Using the Least AbsoluteShrinkag e and Selection Operator (Lasso) regressionand Support Vector Machine-Recursive Feature Elimination (SVM-RFE), common diagnostic markers for both diseases were further evaluated. Then, we utilizedthe CIBERSORT method to assess the abundance of immune cell infiltration. Finally,we used the single-cell analysis to obtain the location of common diagnostic markers. 71 common driver genes were identifi ed in the SLE and IBD cohorts based on the DEGs and module genes. KEGG and GO en richment results showed that these genes were closely associated with positive r egulation of programmed cell death and inflammatory responses. By using LASSO re gression and SVM, five hub genes (KLRF1, GZMK, KLRB1, CD40LG, and IL-7R) were ul timately determined as common diagnostic markers for SLE and IBD. ROC curve anal ysis also showed good diagnostic performance. The outcomes of immune cell infilt ration demonstrated that SLE and IBD shared almost identical immune infiltration patterns. Furthermore, the majority of the hub genes were commonly expressed in NK cells by single-cell analysis. This study demonstrates that SLE and IBD shar e common diagnostic markers and pathogenic pathways.”
NantongPeople’s Republic of ChinaAsi aAutoimmune Diseases and ConditionsBiomarkersBowel Diseases and ConditionsDiagnostics and ScreeningDigestive System Diseases and ConditionsGastroent eritisGastrointestinal Diseases and ConditionsGeneticsHealth and MedicineInflammatory Bowel DiseaseLupusSystemic Lupus Erythematosus
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