首页|A combinatorially complete epistatic fitness landscape in an enzyme active site
A combinatorially complete epistatic fitness landscape in an enzyme active site
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews – According to news reporting based on a preprint a bstract, our journalists obtained the followingquote sourced from biorxiv.org:“Protein engineering often targets binding pockets or active sites which are enr iched in epistasis–non-additive interactions between amino acid substitutions– and where the combined effects of multiplesingle substitutions are difficult to predict. Few existing sequence-fitness datasets capture epistasis at largescal e, especially for enzyme catalysis, limiting the development and assessment of m odel-guided enzymeengineering approaches.
BioengineeringBiotechnologyCombinato rialCombinatoricCyborgsEmerging TechnologiesEngineeringEnzymes and Coe nzymesMachine Learning
NETL
NSTL
