首页|Leveraging Machine Learning and AlphaFold2 Steering to Discover State-Specific I nhibitors Across the Kinome
Leveraging Machine Learning and AlphaFold2 Steering to Discover State-Specific I nhibitors Across the Kinome
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By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News - According to news reporting based on a preprint abstract, our journalists obtained thefollowing quote sourced from bi orxiv.org:“Protein kinases are structurally dynamic proteins that control downstream signa ling cascades byphosphorylating their substrates. Protein kinases regulate thei r function by adopting several conformationalstates in their active site determ ined by the movements of several motifs such as the C-Helix, DFG residuesand th e activation loop. Each conformational state represents a distinct physicochemic al environmentthat accepts or precludes ligand binding.
BioinformaticsBiotechnologyBiotechno logy - BioinformaticsCyborgsEmerging TechnologiesEnzymes and CoenzymesIn formation TechnologyKinaseMachine Learning
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