首页|Researchers from Xiangtan University Describe Findings in Machine Learning (Mach ine Learning-based Fluorescence Sensor Array: Accurate Discrimination, Quantitat ive Assay of Phenothiazine Drugs Via Versatile Dna Probes)
Researchers from Xiangtan University Describe Findings in Machine Learning (Mach ine Learning-based Fluorescence Sensor Array: Accurate Discrimination, Quantitat ive Assay of Phenothiazine Drugs Via Versatile Dna Probes)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – Investigators discuss new findings in Machine Learning. According to news reporting originating from Xiangtan, People’ s Republic of China, by NewsRx correspondents, research stated, “Phenothiazine d rugs are widely used to treat psychotic diseases in humans. The phenothiazine li gand enables unique interaction between the drugs and DNA double helix.” Financial supporters for this research include National Natural Science Foundati on of China (NSFC), Natural Science Foundation of Hunan Province, Project of Hun an Provincial Department of Edu-cation. Our news editors obtained a quote from the research from Xiangtan University, “W e discovered that it was impossible to select aptamer to selectively bind with p henothiazine drug. In this study, an alternative fluorescence sensor array was f irst developed to accurately discriminate four typical phenothiazine drugs based on machine learning. As the eight sensor elements, versatile DNA probes were de signed based on different oligonucleotides, two unique fluorescence dyes, and di verse buffer solutions. The fingerprint data can offer the fluorescence response patterns against each phenothiazine drug. Linear discriminant analysis (LDA) ca n discriminate single one or mixture samples of phenothiazine drugs with 100% accuracy. Besides, one neural network model showed a good linear relationship be tween predicted and actual concentrations to quantitatively assay specific pheno thiazine drugs.”
XiangtanPeople’s Republic of ChinaAs iaCyborgsDNA ProbesDrugs and TherapiesEmerging TechnologiesLaboratory ChemicalsMachine LearningNucleic Acid ProbesPhenothiazinesSulfur Compoun dsXiangtan University
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