首页|Guangdong Medical University Reports Findings in Acute Kidney Injury (CDKN1A Pro motes Cis-induced AKI by Inducing Cytoplasmic ROS Production and Ferroptosis)
Guangdong Medical University Reports Findings in Acute Kidney Injury (CDKN1A Pro motes Cis-induced AKI by Inducing Cytoplasmic ROS Production and Ferroptosis)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – New research on Kidney Diseases and Co nditions - Acute Kidney Injury is the subject of a report. According to news rep orting out of Guangdong, People’s Republic of China, by NewsRx editors, research stated, “This study focuses on investigating the role of CDKN1A in cisplatin-in duced AKI ( acute kidney injury, AKI) and its potential as a biomarker for early diagnosis and therapeutic intervention by integrating bioinformatics analysis, machine learning, and experimental validation. We analyzed the GSE85957 dataset to find genes that changed between control and cisplatin-treated rats.” Our news journalists obtained a quote from the research from Guangdong Medical U niversity, “Using bioinformatics and machine learning, we found 13 important gen es related to ferroptosis and the P53 pathway. The key gene, CDKN1A, was identif ied using various algorithms. We then tested how reducing CDKN1A in human kidney cells affected cell health, ROS, and iron levels. We also checked how CDKN1A ch anges the levels of proteins linked to ferroptosis using Q-PCR and Western Blot. CDKN1A was found to negatively regulate the G1/S phase transition and was assoc iated with ferroptosis in p53 signaling. Experiments in human renal tubular epit helial cells (HK-2) and rat NRK-52E cells showed that CDKN1A knockdown mitigated cisplatin-induced cell injury by reducing oxidative stress and ferroptosis. Our integrated approach identified CDKN1A as a biomarker for cisplatin-induced AKI. ”
GuangdongPeople’s Republic of ChinaA siaAcute Kidney InjuryAlkylating AgentsAntineoplasticsBiomarkersChlori ne CompoundsCisplatin TherapyCyborgsCytoplasmDiagnostics and ScreeningDrugs and TherapiesEmerging TechnologiesHealth and MedicineIntracellular S paceKidney Diseases and ConditionsMachine LearningNitrogen CompoundsPhar maceuticalsPlatinum Compounds
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