首页|'Interferometric Scattering Microscopy' in Patent Application Approval Process ( USPTO 20240344979)
'Interferometric Scattering Microscopy' in Patent Application Approval Process ( USPTO 20240344979)
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The following quote was obtained by the news editors from the background informa tion supplied by the inventors: “iSCAT has materialized as a powerful approach t o both single particle tracking with unique spatiotemporal resolution and label- free sensitivity down to the single molecule level.iSCAT is disclosed, for exam ple in Kukura et al., “High-speed nanoscopic tracking of the position and orient ation of a single virus”, Nature Methods 2009 6:923-935, and in Ortega-Arroyo et al.“Interferometric scattering microscopy (iSCAT): new frontiers in ultrafast and ultra-sensitive optical microscopy”, Physical Chemistry Chemical Physics 201 2 14:15625-15636.Despite considerable potential, widespread application of iSCA T has been limited by the requirement for custom-built microscopes, unconvention al cameras and complex sample illumination, limiting the capabilities of iSCAT f or the robust and accurate detection, imaging and characterisation of objects as small as single molecules.
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