首页|Integrating Bioinformatics and Artificial Intelligence Methods to identify disru ptive STAT1 variants impacting Protein Stability and Function
Integrating Bioinformatics and Artificial Intelligence Methods to identify disru ptive STAT1 variants impacting Protein Stability and Function
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By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from bi orxiv.org: “The Signal Transducer and Activator of Transcription 1 (STAT1) gene is an essen tial component of the JAK-STAT signaling pathway. “This pathway has a pivotal role in regulating different cellular processes, inc luding immune responses, cell growth, and apoptosis. Mutations in the STAT1 gene contribute to various body pathologies [OMIM #6 00555], including immune system dysfunction. “In the current study, we used eighteen online computational approaches. Six pat hogenic variants (R602W, I648T, V642D, L600P, I578N, and W504C) were predicted t o significantly disrupt protein stability and function.
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