首页|Chinese Academy of Sciences Reports Findings in Brain-Based Devices(Enhanced ne ural activity detection with microelectrode arraysmodified by drug-loaded calci um alginate/chitosan hydrogel)
Chinese Academy of Sciences Reports Findings in Brain-Based Devices(Enhanced ne ural activity detection with microelectrode arraysmodified by drug-loaded calci um alginate/chitosan hydrogel)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News – New research on Brain-Based Devices is the subject of a report. According to newsoriginating from Beijing, People’s R epublic of China, by NewsRx correspondents, research stated, “Microelectrodearr ays (MEAs) are pivotal brain-machine interface devices that facilitate in situ a nd real-timedetection of neurophysiological signals and neurotransmitter data w ithin the brain. These capabilities areessential for understanding neural syste m functions, treating brain disorders, and developing advancedbrain-machine int erfaces.”Our news journalists obtained a quote from the research from the Chinese Academy of Sciences, “Toenhance the performance of MEAs, this study developed a crossl inked hydrogel coating of calcium alginate(CA) and chitosan (CS) loaded with th e anti-inflammatory drug dexamethasone sodium phosphate(DSP). By modifying the MEAs with this hydrogel and various conductive nanomaterials, including platinumnanoparticles (PtNPs) and poly (3,4-ethylenedioxythiophene) polystyrene sulfona te (PEDOT: PSS), theelectrical properties and biocompatibility of the electrode s were optimized. The hydrogel coating matchesthe mechanical properties of brai n tissue more effectively and, by actively releasing anti-inflammatorydrugs, si gnificantly reduces post-implantation tissue inflammation, extends the electrode s’ lifespan, andenhances the quality of neural activity detection. Additionally , this modification ensures high sensitivityand specificity in the detection of dopamine (DA), displaying high-quality dual-mode neural activityduring in vivo testing and revealing significant functional differences between neuron types u nder variousphysiological states (anesthetized and awake). Overall, this study showcases the significant applicationvalue of bioactive hydrogels as excellent nanobiointerfaces and drug delivery carriers for long-term neuralmonitoring.”
BeijingPeople’s Republic of ChinaAsi aAlcoholsBrain-Based DevicesBrain-machine InterfaceEmerging TechnologiesHydrogelMachine LearningOrganicChemicalsPolyethylene Glycols
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