首页|Beijing Hospital Reports Findings in Bladder Cancer (Dynamic landscapeof m6A mo difications and related post-transcriptional eventsin muscle-invasive bladder c ancer)
Beijing Hospital Reports Findings in Bladder Cancer (Dynamic landscapeof m6A mo difications and related post-transcriptional eventsin muscle-invasive bladder c ancer)
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By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News – New research on Oncology - Bladder Can cer is the subject of a report. According tonews reporting originating from Bei jing, People’s Republic of China, by NewsRx correspondents, researchstated, “Mu scle-invasive bladder carcinoma (MIBC) is a serious and more advanced stage of b laddercarcinoma. N6-Methyladenosine (m6A) is a dynamic and reversible modificat ions that primarily affectsRNA stability and alternative splicing.”Our news editors obtained a quote from the research from Beijing Hospital, “The dysregulation of m6Ain MIBC can be potential target for clinical interventions, but there have been limited studies on m6Amodifications in MIBC and their asso ciations with post-transcriptional regulatory processes. Paired tumorand adjace nt-normal tissues were obtained from three patients with MIBC following radical cystectomy.The additional paired tissues for validation were obtained from pati ents underwent transurethral resection.Utilizing Nanopore direct-RNA sequencing , we characterized the m6A RNA methylation landscape in MIBC, with a focus on id entifying post-transcriptional events potentially affected by changes in m6A sites. This included an examination of differential transcript usage, polyadenylati on signal sites, and variationsin poly(A) tail length, providing insights into the broader impact of m6A alterations on RNA processing inMIBC. The prognostic- related m6A genes and m6A-risk model constructed by machine learning enablesthe stratification of high and low-risk patients with precision. A novel m6A modifi cation site in the 3’untranslated region (3’UTR) of IGLL5 gene were identified, characterized by a lower m6A methylationratio, elongated poly(A) tails, and a notable bias in transcript usage. Furthermore, we discovered twoparticular tran scripts, VWA1-203 and CEBPB-201. VWA1-203 displayed diminished m6A methylation levels, a truncated 3’UTR, and an elongated poly(A) tail, whereas CEBPB-201 showe d opposite trends,highlighting the complex interplay between m6A modifications and RNA processing.
BeijingPeople’s Republic of ChinaAsi aBladder CancerCancerCyborgsEmerging TechnologiesGeneticsHealth and MedicineMachine LearningOncology
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